GENE EXPRESSION ON ARRAY TOOLS

Microarray is an important part of life science domain to analyze the expressions of genes and this is due to the rapid progress of Human Genome Project and Biotechnology. The use of gene expression profiling has increased dramatically but serious problems are in the analysis of such data. Valid analysis of DNA microarray experiments requires substantial statistical knowledge but statisticians with expertise in microarray methods are in short supply and not available to many laboratories.

BRB-Array Tools was developed in an attempt to broadly share the knowledge gained by biostatisticians of the Biometric Research Branch of the National Cancer Institute in a decade of involvement in collaborative microarray investigations and in the development of statistical methodology for microarray data. The primary objectives of BRB-Array Tools are:

(1) To provide scientists with software that guides them to utilize valid and powerful methods appropriate for their experimental objectives without requiring them to learn a programming language.

(2) To encapsulate into software the experience of professional statisticians who read and critically evaluate the extensive published literature of new analytic and computational methods.

(3) To facilitate education of scientists in statistical methods for the analysis of DNA microarray data.

BRB-Array Tools is an integrated software system for the comprehensive analysis of DNA microarray experiments. It was developed by professional biostatisticians experienced in the design and analysis of DNA microarray studies and incorporates methods developed by leading statistical laboratories. The software is designed for use by biomedical scientists who wish to have access to state-of-the-art statistical methods for the analysis of gene expression data and to receive training in the statistical analysis of high dimensional data. The software provides the most extensive set of tools available for predictive classifier development and complete cross-validation. It offers extensive links to genomic websites for gene annotation and analysis tools for pathway analysis. An archive of over 100 datasets of published microarray data with associated clinical data is provided and BRB-Array Tools automatically imports data from the Gene Expression Omnibus public archive at the National Center for Biotechnology Information. So anyone who is working for expression of genes can go for it.

Author Name

Bashah Javed

Faculty Bioinformatics

Bioinformatics Institute of India